Mark Cooper may refer to:
- Mark Anthony Cooper (1800–1885), American congressman
- Mark Cooper (academic), senior research fellow for economic analysis
- Mark Cooper (footballer, born 1967), English football player for Leyton Orient F.C. and Northampton Town F.C.
- Mark Cooper (footballer, born 1968), English football manager of Yeovil Town F.C., former player
- Mark Cooper (American football) (born 1960), former American football guard in the National Football League for the Denver Broncos and the Tampa Bay Buccaneers
- Mark Cooper (artist) (born 1950), American multimedia artist
- Mark Cooper (judge), New Zealand judge
- Mark Cooper, the title character of the sitcom Hangin' with Mr. Cooper