Masitinib

Masitinib
Clinical data
Trade names	Masivet, Kinavet
AHFS/Drugs.com	International Drug Names
ATC code	L01EX06 (WHO) ;
Identifiers
	IUPAC name 4-[(4-Methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)-1,3-thiazol-2-yl]amino}phenyl)benzamide;
CAS Number	790299-79-5;
PubChem CID	10074640;
ChemSpider	8250179;
UNII	M59NC4E26P;
KEGG	D10229;
ChEMBL	ChEMBL1908391;
PDB ligand	G65 (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID001000207 ;
Chemical and physical data
Formula	C28H30N6OS
Molar mass	498.65 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(c1ccc(cc1)CN2CCN(C)CC2)Nc3cc(c(cc3)C)Nc4nc(cs4)c5cccnc5;
	InChI InChI=InChI=1S/C28H30N6OSc1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34h3-11,16-17,19H,12-15,18H2,1-2H3,(H,30,35)(H,31,32); Key:WJEOLQLKVOPQFV-UHFFFAOYSA-N;

Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumours in animals, specifically dogs.^[1]^[2] Since its introduction in November 2008 it has been distributed under the commercial name Masivet. It has been available in Europe since the second part of 2009. Masitinib has been studied for several human conditions including melanoma, multiple myeloma, gastrointestinal cancer, pancreatic cancer, Alzheimer disease, multiple sclerosis, rheumatoid arthritis, mastocytosis, amyotrophic lateral sclerosis and COVID-19.^[3]^[4]^[5]

^ Hahn KA, Ogilvie G, Rusk T, Devauchelle P, Leblanc A, Legendre A, et al. (2008). "Masitinib is safe and effective for the treatment of canine mast cell tumors". Journal of Veterinary Internal Medicine. 22 (6): 1301–1309. doi:10.1111/j.1939-1676.2008.0190.x. PMID 18823406.{{cite journal}}: CS1 maint: overridden setting (link)
^ Information about Masivet Archived 15 November 2017 at the Wayback Machine at the European pharmacy agency website
^ Drayman N, DeMarco JK, Jones KA, Azizi SA, Froggatt HM, Tan K, et al. (August 2021). "Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2". Science. 373 (6557): 931–936. Bibcode:2021Sci...373..931D. doi:10.1126/science.abg5827. PMC 8809056. PMID 34285133.{{cite journal}}: CS1 maint: overridden setting (link)
^ "Orphan designation EU/3/16/1722 for masitinib mesilate for the treatment of amyotrophic lateral sclerosis". European Medicines Agency. 17 September 2018. Archived from the original on 17 October 2017. Retrieved 29 November 2016.
^ Folch J, Petrov D, Ettcheto M, Pedrós I, Abad S, Beas-Zarate C, et al. (June 2015). "Masitinib for the treatment of mild to moderate Alzheimer's disease". Expert Review of Neurotherapeutics. 15 (6): 587–596. doi:10.1586/14737175.2015.1045419. PMID 25961655. S2CID 39839943.{{cite journal}}: CS1 maint: overridden setting (link)