North-south state highway in Massachusetts, US
Route 181 is a 9.43-mile-long (15.18 km) north–south state highway in Massachusetts starting at an intersection with U.S. Route 20 in Palmer, located in Hampden County. The route crosses the Mass Pike (Interstate 90), but does not intersect. The route crosses through the Bondsville section of Palmer, crossing into Hampshire County, where it enters Belchertown. In Belchertown, Route 181 comes to an end at a junction with the concurrent U.S. Route 202 (US 202) and Route 21.