The Massachusetts smallpox epidemic or colonial epidemic was a smallpox outbreak that hit Massachusetts in 1633.[1] Smallpox outbreaks were not confined to 1633 however, and occurred nearly every ten years.[2] Smallpox was caused by two different types of variola viruses: variola major and variola minor.[3] The disease was hypothesized to be transmitted due to an increase in the immigration of European settlers to the region who brought Old World smallpox aboard their ships.[4]
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