Matthew Todd (chemist)

Matthew H. Todd
Born
Matthew Houghton Todd

(1973-01-13) 13 January 1973 (age 51)
Manchester, United Kingdom
Alma materUniversity of Cambridge
Known forOpen Source Malaria
Open Source Tuberculosis
Open Source Mycetoma
Scientific career
Fields
Institutions
ThesisNovel encoding strategies for combinatorial chemistry (1998)
Doctoral advisorChris Abell
Other academic advisorsPaul A. Bartlett
Notable studentsAlice Motion
WebsiteThe Todd Group

Matthew Houghton Todd (born 13 January 1973) is a British chemist and the Professor and Chair of Drug Discovery of the School of Pharmacy at University College London.[1] He is the founder of Open Source Malaria (OSM) and his research focuses on drug discovery and development for this disease.[2][3][4][5][6] Recently, he has expanded to other areas, particularly neglected diseases such as tuberculosis and mycetoma[7] in the Open Source Tuberculosis (OSTB) and Open Source Mycetoma (MycetOS) project, through a collaboration with the Drugs for Neglected Diseases Initiative and Erasmus MC.[8] In addition, he has some research activity in catalysis and methodology.[9][10][11][12]

  1. ^ "Professor Matthew Todd – UCL School of Pharmacy". 2 October 2018.
  2. ^ Peplow, M (2019). "Open-source drug discovery takes aim at malaria and neglected diseases". C&EN. ACS. Retrieved 13 February 2019.
  3. ^ Lowe, D. "The Open Source Malaria Project, So Far". In The Pipeline. Retrieved 13 February 2019.
  4. ^ Williamson, AE (2016). "Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles". ACS Central Science. 2 (10): 687–701. doi:10.1021/acscentsci.6b00086. PMC 5084075. PMID 27800551.
  5. ^ Robertson, MN (2014). "Open source drug discovery – A limited tutorial". Parasitology. 141 (1): 148–157. doi:10.1017/S0031182013001121. PMC 3884843. PMID 23985301.
  6. ^ Tse, EG; Korsik, M; Todd, MH (2019). "The past, present and future of anti-malarial medicines". Malaria Journal. 18 (1): 93. doi:10.1186/s12936-019-2724-z. PMC 6431062. PMID 30902052.
  7. ^ Lim, W (2018). "Addressing the most neglected diseases through an open research model: The discovery of fenarimols as novel drug candidates for eumycetoma". PLOS Neglected Tropical Diseases. 12 (2): e0006437. doi:10.1371/journal.pntd.0006437. PMC 5940239. PMID 29698504.
  8. ^ "MycetOS – DNDi". 31 December 2017.
  9. ^ Park, SJ (2002). "Oxidative Arylation of Isochroman". Journal of Organic Chemistry. 77 (2): 949–955. doi:10.1021/jo2021373. PMID 22142205.
  10. ^ Tsang, ASK (2009). "Facile synthesis of vicinal diamines via oxidation of N-phenyltetrahydroisoquinolines with DDQ". Tetrahedron Letters. 50 (11): 1199–1202. doi:10.1016/j.tetlet.2008.12.101.
  11. ^ Hashmi, ASK (2010). "Gold-Catalysis: Reactions of Organogold Compounds with Electrophiles". Australian Journal of Chemistry. 63 (12): 1619–1626. doi:10.1071/CH10342.
  12. ^ Ahamed, M (2010). "Catalytic Asymmetric Additions of Carbon-Centered Nucleophiles to Nitrogen-Containing Aromatic Heterocycles". European Journal of Organic Chemistry. 2010 (31): 5935–5942. doi:10.1002/ejoc.201000877.