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Maturation-promoting factor (abbreviated MPF, also called mitosis-promoting factor or M-Phase-promoting factor) is the cyclin–Cdk complex that was discovered first in frog eggs.[1][2] It stimulates the mitotic and meiotic phases of the cell cycle. MPF promotes the entrance into mitosis (the M phase) from the G2 phase by phosphorylating multiple proteins needed during mitosis. MPF is activated at the end of G2 by a phosphatase, which removes an inhibitory phosphate group added earlier.
The MPF is also called the M phase kinase because of its ability to phosphorylate target proteins at a specific point in the cell cycle and thus control their ability to function.
- ^ Smith LD, Ecker RE (June 1971). "The interaction of steroids with Rana pipiens Oocytes in the induction of maturation". Developmental Biology. 25 (2): 232–47. doi:10.1016/0012-1606(71)90029-7. PMID 5562852.
- ^ Masui Y, Markert CL (June 1971). "Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes". The Journal of Experimental Zoology. 177 (2): 129–45. doi:10.1002/jez.1401770202. PMID 5106340.