McLain is a surname. Notable people with the surname include:
- Carrie M. McLain, American writer, teacher
- Denny McLain, American baseball player
- Ellen McLain, American voice actor
- Hardy McLain (born 1952), American hedge fund manager
- Jeremiah McLain Rusk, American politician, 15th governor of the state of Wisconsin
- Masey McLain, American actress
- Matt McLain, American baseball player
- Raymond S. McLain, American military general
- Tommy McLain, American singer
Fictional characters: