Mdm2

MDM2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RV1, 1T4E, 1T4F, 1YCR, 1Z1M, 2AXI, 2C6A, 2C6B, 2FOP, 2GV2, 2HDP, 2LZG, 2M86, 2MPS, 2RUH, 2VJE, 2VJF, 3EQS, 3G03, 3IUX, 3IWY, 3JZK, 3JZR, 3JZS, 3LBK, 3LBL, 3LNJ, 3LNZ, 3MQS, 3TJ2, 3TPX, 3TU1, 3V3B, 3VBG, 3VZV, 3W69, 4DIJ, 4ERE, 4ERF, 4HBM, 4HFZ, 4HG7, 4JV7, 4JV9, 4JVE, 4JVR, 4JWR, 4MDN, 4MDQ, 4OAS, 4OBA, 4OCC, 4ODE, 4ODF, 4OGN, 4OGT, 4OGV, 4OQ3, 4QO4, 4QOC, 4UMN, 4WT2, 4XXB, 4ZYC, 4ZYF, 4ZYI, 4UE1, 4UD7, 5AFG, 5HMI, 5HMK, 5HMH, 5C5A
Identifiers
Aliases	MDM2, ACTFS, HDMX, hdm2, MDM2 proto-oncogene, LSKB
External IDs	OMIM: 164785; MGI: 96952; HomoloGene: 1793; GeneCards: MDM2; OMA:MDM2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q15 Start 68,808,177 bp[1] End 68,845,544 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 D2|10 66.32 cM Start 117,524,780 bp[2] End 117,546,663 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ventricular zone right uterine tube olfactory zone of nasal mucosa sural nerve epithelium of colon epithelium of nasopharynx stromal cell of endometrium right lobe of liver ganglionic eminence Top expressed in zygote gastrula seminiferous tubule spermatocyte granulocyte spermatid aortic valve secondary oocyte ascending aorta muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function scaffold protein binding protein binding enzyme binding metal ion binding identical protein binding ubiquitin protein ligase binding p53 binding SUMO transferase activity ubiquitin-protein transferase activity transferase activity ligase activity 5S rRNA binding zinc ion binding ribonucleoprotein complex binding protein N-terminus binding ubiquitin protein ligase activity NEDD8 ligase activity disordered domain specific binding protein domain specific binding receptor serine/threonine kinase binding peroxisome proliferator activated receptor binding ubiquitin binding Cellular component cytosol endocytic vesicle membrane plasma membrane synapse nuclear body cytoplasm nucleus nucleoplasm nucleolus protein-containing complex Biological process negative regulation of signal transduction by p53 class mediator endocardial cushion morphogenesis cellular response to UV-C atrial septum development regulation of heart rate DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest positive regulation of gene expression blood vessel development positive regulation of cell population proliferation negative regulation of DNA damage response, signal transduction by p53 class mediator response to ether blood vessel remodeling cellular response to hypoxia heart valve development cellular response to estrogen stimulus negative regulation of apoptotic process cellular response to organic substance cellular response to hydrogen peroxide response to cocaine cardiac septum morphogenesis negative regulation of transcription by RNA polymerase II peptidyl-lysine modification positive regulation of cell cycle ventricular septum development positive regulation of protein export from nucleus response to steroid hormone cellular response to growth factor stimulus regulation of protein catabolic process cellular response to antibiotic negative regulation of gene expression positive regulation of mitotic cell cycle heart development cellular response to alkaloid cellular response to vitamin B1 response to magnesium ion negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process cellular response to peptide hormone stimulus cellular response to organic cyclic compound viral process response to iron ion regulation of gene expression response to antibiotic traversing start control point of mitotic cell cycle protein ubiquitination negative regulation of protein processing establishment of protein localization response to toxic substance response to morphine atrioventricular valve morphogenesis protein localization to nucleus regulation of signal transduction by p53 class mediator positive regulation of vascular associated smooth muscle cell proliferation response to water-immersion restraint stress negative regulation of neuron projection development positive regulation of vascular associated smooth muscle cell migration protein deubiquitination protein sumoylation transcription factor catabolic process protein autoubiquitination response to formaldehyde protein destabilization negative regulation of transcription, DNA-templated proteolysis involved in cellular protein catabolic process cellular response to gamma radiation cellular response to actinomycin D negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator amyloid fibril formation protein-containing complex assembly ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4193 17246 Ensembl ENSG00000135679 ENSMUSG00000020184 UniProt Q00987 P23804 RefSeq (mRNA) NM_001145336 NM_001145337 NM_001145339 NM_001145340 NM_001278462 NM_002392 NM_006878 NM_006879 NM_006880 NM_006881 NM_006882 NM_032739 NM_001367990 NM_001288586 NM_010786 RefSeq (protein) NP_001138809 NP_001138811 NP_001138812 NP_001265391 NP_002383 NP_001354919 NP_001275515 NP_034916 Location (UCSC) Chr 12: 68.81 – 68.85 Mb Chr 10: 117.52 – 117.55 Mb PubMed search [3] [4]
Wikidata
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Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene.^[5][6] Mdm2 is an important negative regulator of the p53 tumor suppressor. Mdm2 protein functions both as an E3 ubiquitin ligase that recognizes the N-terminal trans-activation domain (TAD) of the p53 tumor suppressor and as an inhibitor of p53 transcriptional activation.