Meacham is a surname. Notable people with the surname include:
- Alfred B. Meacham (1826–1882), U.S. Superintendent of Indian Affairs for Oregon (1869–1872)
- Bob Meacham (born 1960), American Major League Baseball player
- Doug Meacham (born 1964), American football coach
- Ellis K. Meacham (1913–1998), author and jurist
- F. W. Meacham (1856–1909), American composer
- John A. Meacham (born 1944), American professor
- Jon Meacham (born 1969), AMerican journalist, biographer of American presidents
- Joseph Meacham (1742–1796), early leader of the Shakers
- Mildred Meacham (1924–2017), All-American Girls Professional Baseball League player
- William Meacham, American archaeologist specializing in South China