The state of medical knowledge at the time of the Civil War was quite limited by 21st century standards. Doctors did not understand germs, and did little to prevent infection. It was a time before antiseptics, and a time when there was no attempt to maintain sterility during surgery. No antibiotics were available, and minor wounds could easily become infected, and hence fatal. While the typical soldier was at risk of being hit by rifle or artillery fire, he faced an even greater risk of dying from disease.