Mefenamic acid

Mefenamic acid
Clinical data
Trade namesPonstel, Ponstan, others
AHFS/Drugs.comMonograph
MedlinePlusa681028
Pregnancy
category
  • AU: C
Routes of
administration		By mouth, rectal
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability90%
Protein binding>90%
MetabolismLiver (CYP2C9)
Elimination half-life2 hours
ExcretionKidney (52–67%), faeces (20–25%)
Identifiers
  • 2-(2,3-dimethylphenyl)aminobenzoic acid
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.000.467 Edit this at Wikidata
Chemical and physical data
FormulaC15H15NO2
Molar mass241.290 g·mol−1
3D model (JSmol)
  • O=C(O)c2c(Nc1cccc(c1C)C)cccc2
  • InChI=1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/h3-9,16H,1-2H3,(H,17,18) checkY
  • Key:HYYBABOKPJLUIN-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Mefenamic acid is a member of the anthranilic acid derivatives (or fenamate) class of nonsteroidal anti-inflammatory drugs (NSAIDs), and is used to treat mild to moderate pain.[4][5]

Its name derives from its systematic name, dimethylphenylaminobenzoic acid. It was discovered and brought to market by Parke-Davis as Ponstel in the 1960s. It became generic in the 1980s and is available worldwide under many brand names such as Meftal.[6]

  1. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
  2. ^ "Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 30 March 2024.
  3. ^ "Product monograph brand safety updates". Health Canada. 6 June 2024. Retrieved 8 June 2024.
  4. ^ "Ponstel Label" (PDF). U.S. Food and Drug Administration. 19 February 2008.
  5. ^ Cite error: The named reference Pringsheim was invoked but never defined (see the help page).
  6. ^ Cite error: The named reference BrandNames was invoked but never defined (see the help page).