| Megapterygius Temporal range: Late Cretaceous (Maastrichtian),
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| Size of Megapterygius compared to a human | |
Scientific classification 
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| Domain: | Eukaryota |
| Kingdom: | Animalia |
| Phylum: | Chordata |
| Class: | Reptilia |
| Order: | Squamata |
| Clade: | †Mosasauria |
| Family: | †Mosasauridae |
| Subfamily: | †Mosasaurinae |
| Genus: | †Megapterygius Konishi et al., 2023 |
| Type species | |
| †Megapterygius wakayamaensis Konishi et al., 2023
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Megapterygius (meaning "large wing") is an extinct genus of mosasaurine mosasaur from the Late Cretaceous Toyajo Formation (Hasegawa Muddy Sandstone Member) of Japan. The genus contains a single species, M. wakayamaensis, known from an almost complete skeleton.