Mehoopany Creek is a tributary of the Susquehanna River in Sullivan and Wyoming counties, Pennsylvania, in the United States. It is approximately 26.8 miles (43.1 km) long. In Sullivan County the creek flows through Colley Township and in Wyoming County it flows through Forkston Township and Mehoopany Township.[1] The stream's watershed has an area of 123 square miles (320 km2). Its major tributaries include Stony Brook and North Fork Mehoopany Creek.
Mehoopany Creek is designated as a high-quality coldwater fishery in Sullivan County. Its headwaters are listed in the Sullivan County Natural Areas Inventory.