Melancthon Smith Wade | |
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| Born | December 2, 1802 Cincinnati, Ohio |
| Died | August 11, 1868 (aged 65) Avondale, Ohio |
| Place of burial | Spring Grove Cemetery, Cincinnati, Ohio |
| Allegiance | United States of America Union |
| Service | United States Army Union Army |
| Years of service | 1861–1862 |
| Rank |  Brigadier general |
| Commands | Camp Dennison |
| Battles / wars | American Civil War |
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Melancthon Smith Wade (December 2, 1801 – August 11, 1868) was a businessman, horticulturist, and soldier from the state of Ohio who served as a general in the Union Army during the early part of the American Civil War.