Melanin-concentrating hormone

Melanin-concentrating hormone
Identifiers
SymbolPMCH
CAS number67382-96-1
NCBI gene5367
HGNC9109
OMIM176795
RefSeqNM_002674
UniProtP20382
Other data
LocusChr. 12 q23.2
Search for
StructuresSwiss-model
DomainsInterPro

Melanin-concentrating hormone (MCH), also known as pro-melanin stimulating hormone (PMCH), is a cyclic 19-amino acid orexigenic hypothalamic peptide originally isolated from the pituitary gland of teleost fish, where it controls skin pigmentation.[1] In mammals it is involved in the regulation of feeding behavior, mood, sleep-wake cycle and energy balance.[2]

  1. ^ Barson JR, Morganstern I, Leibowitz SF (2013). "Complementary roles of orexin and melanin-concentrating hormone in feeding behavior". International Journal of Endocrinology. 2013: 983964. doi:10.1155/2013/983964. PMC 3727095. PMID 23935621.
  2. ^ Verret L, Goutagny R, Fort P, Cagnon L, Salvert D, Léger L, Boissard R, Salin P, Peyron C, Luppi PH (September 2003). "A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep". BMC Neuroscience. 4 (19): 19. doi:10.1186/1471-2202-4-19. PMC 201018. PMID 12964948.