Melperone

Melperone
Skeletal formula of melperone
Space-filling model of the melperone molecule
Clinical data
Trade namesBuronil
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral, intramuscular injection
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability87% (IM), 54% (Oral via syrup), 65% (Oral, tablet)[1]
Protein binding50%
MetabolismHepatic
Elimination half-life3–4 hours (oral)[1]
6 hours (IM)
ExcretionRenal (70% as metabolites, 5.5–10.4% as unchanged drug)[1][2]
Identifiers
  • 1-(4-fluorophenyl)-4-(4-methylpiperidin-1-yl)butan-1-one
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.107.027 Edit this at Wikidata
Chemical and physical data
FormulaC16H22FNO
Molar mass263.356 g·mol−1
3D model (JSmol)
  • Fc1ccc(cc1)C(=O)CCCN2CCC(CC2)C
  • InChI=1S/C16H22FNO/c1-13-8-11-18(12-9-13)10-2-3-16(19)14-4-6-15(17)7-5-14/h4-7,13H,2-3,8-12H2,1H3 checkY
  • Key:DKMFBWQBDIGMHM-UHFFFAOYSA-N checkY
  (verify)

Melperone (Bunil (PT), Buronil (AT, BE, CZ, DK, FI†, NL†, NO†, SE), Eunerpan (DE))[3] is an atypical antipsychotic of the butyrophenone chemical class, making it structurally related to the typical antipsychotic haloperidol. It first entered clinical use in 1960s.[4]

  1. ^ a b c Borgström L, Larsson H, Molander L (1982). "Pharmacokinetics of parenteral and oral melperone in man". European Journal of Clinical Pharmacology. 23 (2): 173–6. doi:10.1007/BF00545974. PMID 7140807. S2CID 36697288.
  2. ^ Cite error: The named reference I1 was invoked but never defined (see the help page).
  3. ^ Cite error: The named reference MD was invoked but never defined (see the help page).
  4. ^ Cite error: The named reference Audit was invoked but never defined (see the help page).