Clinical data | |
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Other names | Mescalin; Mezcalin; Mezcaline; 3,4,5-Trimethoxyphenethylamine; 3,4,5-TMPEA; TMPEA |
AHFS/Drugs.com | mescaline |
Routes of administration | Oral, smoking, insufflation, intravenous[1][2] |
Drug class | Serotonin receptor agonist; Serotonergic psychedelic; Hallucinogen |
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Pharmacokinetic data | |
Metabolism | Oxidative deamination, N-acetylation, O-demethylation, conjugation, other pathways[4][5] |
Metabolites | • 3,4,5-Trimethoxyphenyl-acetaldehyde[4][1] • 3,4,5-Trimethoxyphenylacetic acid[1] • 3,4,5-Trimethoxyphenylethanol[5] • Others[4][5][2] |
Onset of action | Oral: 0.5–3 hours[6][1][2] |
Elimination half-life | 3.6 hours[6][7] |
Duration of action | ≥10–12 hours[6][1][2] |
Excretion | Urine (28–81% unchanged, 13–26% as TMPA)[1][4][5][2] |
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ECHA InfoCard | 100.000.174 |
Chemical and physical data | |
Formula | C11H17NO3 |
Molar mass | 211.261 g·mol−1 |
3D model (JSmol) | |
Density | 1.067 g/cm3 |
Melting point | 35 to 36 °C (95 to 97 °F) |
Boiling point | 180 °C (356 °F) at 12 mmHg |
Solubility in water | moderately soluble in water mg/mL (20 °C) |
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Mescaline, also known as mescalin or mezcalin,[8] as well as 3,4,5-trimethoxyphenethylamine, is a naturally occurring psychedelic protoalkaloid of the substituted phenethylamine class, known for its hallucinogenic effects comparable to those of LSD and psilocybin.[4][1][6][5] It binds to and activates certain serotonin receptors in the brain, producing hallucinogenic effects.[1][6]
Dinis-OliveiraPereiradaSilva2019
was invoked but never defined (see the help page).LeyHolzeArikci2023
was invoked but never defined (see the help page).