Metabotropic glutamate receptor 1

GRM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3KS9, 4OR2
Identifiers
Aliases	GRM1, GPRC1A, MGLU1, MGLUR1, PPP1R85, SCAR13, glutamate metabotropic receptor 1, SCA44
External IDs	OMIM: 604473; MGI: 1351338; HomoloGene: 649; GeneCards: GRM1; OMA:GRM1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q24.3 Start 146,027,646 bp[1] End 146,437,601 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A1 Start 10,561,803 bp[2] End 10,958,100 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus cerebellar vermis middle temporal gyrus endothelial cell Brodmann area 23 cerebellar hemisphere paraflocculus of cerebellum right hemisphere of cerebellum pons optic nerve Top expressed in medial dorsal nucleus medial geniculate nucleus lobe of cerebellum lateral geniculate nucleus cerebellar vermis deep cerebellar nuclei mammillary body superior colliculus globus pallidus lateral hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glutamate receptor activity G protein-coupled receptor activity signal transducer activity protein binding neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration identical protein binding G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential Cellular component integral component of membrane G protein-coupled receptor dimeric complex postsynaptic density membrane G protein-coupled receptor homodimeric complex plasma membrane integral component of plasma membrane dendrite neuron projection nucleus presynaptic membrane Schaffer collateral - CA1 synapse glutamatergic synapse postsynaptic density membrane Biological process cellular response to electrical stimulus G protein-coupled glutamate receptor signaling pathway positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway regulation of MAPK cascade regulation of sensory perception of pain locomotory behavior sensory perception of pain signal transduction chemical synaptic transmission regulation of synaptic transmission, glutamatergic adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway regulation of postsynaptic cytosolic calcium ion concentration G protein-coupled receptor signaling pathway regulation of postsynaptic membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2911 14816 Ensembl ENSG00000152822 ENSMUSG00000019828 UniProt Q13255 P97772 RefSeq (mRNA) NM_000838 NM_001114329 NM_001278064 NM_001278065 NM_001278066 NM_001278067 NM_001114333 NM_016976 RefSeq (protein) NP_001264993 NP_001264994 NP_001264995 NP_001264996 NP_001107805 NP_058672 Location (UCSC) Chr 6: 146.03 – 146.44 Mb Chr 10: 10.56 – 10.96 Mb PubMed search [3] [4]
Wikidata
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The glutamate receptor, metabotropic 1, also known as GRM1, is a human gene which encodes the metabotropic glutamate receptor 1 (mGluR1) protein.^[5][6][7]