Clinical data | |
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Trade names | Skelaxin |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682010 |
License data |
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Routes of administration | By mouth |
ATC code |
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Pharmacokinetic data | |
Bioavailability | Unknown |
Metabolism | Liver |
Elimination half-life | 9.2 ± 4.8 hours |
Excretion | Kidney |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.015.253 |
Chemical and physical data | |
Formula | C12H15NO3 |
Molar mass | 221.256 g·mol−1 |
3D model (JSmol) | |
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Metaxalone, sold under the brand name Skelaxin, is a muscle relaxant medication used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions.[1] Its exact mechanism of action is not known, but it may be due to general central nervous system depression.[1] It is a moderately strong muscle relaxant, with relatively low incidence of side effects.[citation needed]
Common side effects include nausea, vomiting, drowsiness, and central nervous system (CNS) side effects, such as dizziness, headache, and irritability.[1]
The metabolism of metaxalone involves enzymes CYP1A2 and CYP2C19 in the cytochrome P450 system. [medical citation needed] Because many medications are metabolized by enzymes in this system, precaution must be taken when administering it with other medications involving the P450 system to avoid interactions.[2]
Because of the potential for side effects, this drug is considered high risk in the elderly.[medical citation needed]