Metazocine

Not to be confused with Metazosin.
Metazocine
Clinical data
ATC code
  • none
Legal status
Legal status
Identifiers
  • (2R,6R,11R)-3,6,11-Trimethyl-1,2,3,4,5,6-hexahydro-2,6-methanobenzo[d]azocin-8-ol
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.020.998 Edit this at Wikidata
Chemical and physical data
FormulaC15H21NO
Molar mass231.339 g·mol−1
3D model (JSmol)
  • OC1=CC([C@@](C)([C@@]2([H])C)CCN(C)[C@]2([H])C3)=C3C=C1
  • InChI=1S/C15H21NO/c1-10-14-8-11-4-5-12(17)9-13(11)15(10,2)6-7-16(14)3/h4-5,9-10,14,17H,6-8H2,1-3H3 checkY
  • Key:YGSVZRIZCHZUHB-UHFFFAOYSA-N checkY

Metazocine is an opioid analgesic related to pentazocine. While metazocine has significant analgesic effects,[2] mediated through a mixed agonist–antagonist action[3] at the mu opioid receptor,[4] its clinical use is limited by dysphoric and hallucinogenic effects which are most likely caused by activity at kappa opioid receptors (where it is a high-efficacy agonist)[5] and/or sigma receptors.[6][7]

Metazocine is in Schedule II of the Controlled Substances Act 1970 of the United States as a Narcotic with ACSCN 9240 with a 19 gram aggregate manufacturing quota as of 2014. The free base conversion ratio for salts includes 0.81 for the hydrochloride and 0.74 for the hydrobromide.[8] It is listed under the Single Convention for the Control of Narcotic Substances 1961 and is controlled in most countries in the same fashion as is morphine.

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^ Hori M, Ban M, Imai E, Iwata N, Suzuki Y, Baba Y, Morita T, Fujimura H, Nozaki M, Niwa M (November 1985). "Novel nonnarcotic analgesics with an improved therapeutic ratio. Structure-activity relationships of 8-(methylthio)- and 8-(acylthio)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines". Journal of Medicinal Chemistry. 28 (11): 1656–61. doi:10.1021/jm00149a020. PMID 2999399.
  3. ^ Berzetei-Gurske I, Loew GH (1990). "The novel antagonist profile of (-)metazocine". Progress in Clinical and Biological Research. 328: 33–6. PMID 2154788.
  4. ^ Gharagozlou P, Demirci H, David Clark J, Lameh J (January 2003). "Activity of opioid ligands in cells expressing cloned mu opioid receptors". BMC Pharmacology. 3: 1. doi:10.1186/1471-2210-3-1. PMC 140036. PMID 12513698.
  5. ^ Gharagozlou P, Hashemi E, DeLorey TM, Clark JD, Lameh J (January 2006). "Pharmacological profiles of opioid ligands at kappa opioid receptors". BMC Pharmacology. 6: 3. doi:10.1186/1471-2210-6-3. PMC 1403760. PMID 16433932.
  6. ^ Shannon HE (July 1982). "Pharmacological analysis of the phencyclidine-like discriminative stimulus properties of narcotic derivatives in rats". The Journal of Pharmacology and Experimental Therapeutics. 222 (1): 146–51. PMID 7086696.
  7. ^ Slifer BL, Balster RL, May EL (October 1986). "Reinforcing and phencyclidine-like stimulus properties of enantiomers of metazocine". Pharmacology, Biochemistry, and Behavior. 25 (4): 785–9. doi:10.1016/0091-3057(86)90388-6. PMID 3786338. S2CID 32126170.
  8. ^ "Quotas - 2014". Diversion Control Division. U.S. Department of Justice, Drug Enforcement Administration.