Methanol dehydrogenase

In enzymology, a methanol dehydrogenase (MDH) is an enzyme that catalyzes the chemical reaction:

CH₃OH ${\displaystyle \rightleftharpoons }$ CH₂O + 2 electrons + 2H⁺

How the electrons are captured and transported depends upon the kind of methanol dehydrogenase. There are three main types of MDHs: NAD⁺-dependent MDH, pyrrolo-quinoline quinone dependent MDH, and oxygen-dependent alcohol oxidase.^[2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is methanol:NAD⁺ oxidoreductase. This enzyme participates in methane metabolism.