Methoxetamine

Not to be confused with methoxamine, methoxmetamine, methoxyketamine, or methoxpropamine.

Methoxetamine
Clinical data
Other namesMXE; 3-MeO-2'-oxo-PCE
Addiction
liability		High[1]
Drug classNMDA receptor antagonist; Dissociative hallucinogen; General anesthetic
ATC code
  • None
Legal status
Legal status
Pharmacokinetic data
Elimination half-life3–6 hours
Identifiers
  • (R/S)-2-(3-Methoxyphenyl)-2-(ethylamino)cyclohexanone[5]
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC15H21NO2
Molar mass247.338 g·mol−1
3D model (JSmol)
  • O=C1CCCCC1(C2=CC=CC(OC)=C2)NCC
  • InChI=1S/C15H21NO2/c1-3-16-15(10-5-4-9-14(15)17)12-7-6-8-13(11-12)18-2/h6-8,11,16H,3-5,9-10H2,1-2H3 checkY
  • Key:LPKTWLVEGBNOOX-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Methoxetamine (MXE) is a dissociative hallucinogen that has been sold as a designer drug.[5][6] It differs from many dissociatives such as ketamine and phencyclidine (PCP) that were developed as pharmaceutical drugs for use as general anesthetics in that it was designed specifically to increase the antidepressant effects of ketamine.[6][7]

MXE is an arylcyclohexylamine.[8] It acts mainly as an NMDA receptor antagonist, similarly to other arylcyclohexylamines like ketamine and PCP.[8]

  1. ^ Kjellgren A, Jonsson K (2013). "Methoxetamine (MXE)--a phenomenological study of experiences induced by a "legal high" from the internet". Journal of Psychoactive Drugs. 45 (3): 276–286. doi:10.1080/02791072.2013.803647. PMC 3756617. PMID 24175493.
  2. ^ "Federal Register". FederalRegister.gov. 6 June 2022. Retrieved 21 June 2022.
  3. ^ Anvisa (24 July 2023). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 25 July 2023). Archived from the original on 27 August 2023. Retrieved 27 August 2023.
  4. ^ "Substance Details Methoxetamine". Retrieved 22 January 2024.
  5. ^ a b EMCDDA Annual Report 2010 (PDF) (Report). European Monitoring Centre for Drugs and Drug Addiction. 2010. Archived (PDF) from the original on 14 March 2012. Retrieved 23 January 2012.
  6. ^ a b Morris H, Wallach J (2014). "From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs". Drug Testing and Analysis. 6 (7–8): 614–632. doi:10.1002/dta.1620. PMID 24678061.
  7. ^ Morris H (11 February 2011). "Interview with a ketamine chemist: or to be more precise, an arylcyclohexylamine chemist". Vice Magazine. Archived from the original on 30 January 2012. Retrieved 23 January 2012.
  8. ^ a b Cite error: The named reference pmid23527166 was invoked but never defined (see the help page).