Methyl-CpG-binding domain protein 2

MBD2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L2L
Identifiers
Aliases	MBD2, DMTase, NY-CO-41, methyl-CpG binding domain protein 2
External IDs	OMIM: 603547; MGI: 1333813; HomoloGene: 2918; GeneCards: MBD2; OMA:MBD2 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	54,224,669 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	70,759,202 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; tonsil; ; epithelium of colon; ; oral cavity; ; bone marrow cells; ; parotid gland; ; white blood cell; ; sural nerve; ; mucosa of esophagus; ; monocyte;
	Top expressed in
	epithelium of urethra; ; granulocyte; ; Paneth cell; ; epithelium of male urethra; ; epithelium of female urethra; ; hair follicle; ; aortic valve; ; ascending aorta; ; lip; ; submandibular gland;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; protein domain specific binding; methyl-CpG binding; C2H2 zinc finger domain binding; chromatin binding; protein binding; siRNA binding; nucleosomal DNA binding; satellite DNA binding; mRNA binding;
Cellular component	cytoplasm; histone deacetylase complex; heterochromatin; chromatin; nucleus; nucleoplasm; cytosol; protein-containing complex;
Biological process	regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of Wnt signaling pathway; regulation of cell population proliferation; maternal behavior; negative regulation of transcription, DNA-templated; human ageing; response to mechanical stimulus; response to estradiol; cellular response to organic cyclic compound; response to nutrient levels; response to organic cyclic compound; positive regulation of chromatin binding; heart development; embryonic organ development; rDNA heterochromatin assembly; regulation of DNA methylation; DNA methylation-dependent heterochromatin assembly;
	Sources:Amigo / QuickGO
Orthologs
	8932
	17191
	ENSG00000134046
	ENSMUSG00000024513
	Q9UBB5
	Q9Z2E1
	NM_015832; NM_003927
	NM_010773; NM_001311071
	NP_003918; NP_056647; NP_056647.1
	NP_001298000; NP_034903
	Wikidata
View/Edit Human	View/Edit Mouse

Methyl-CpG-binding domain protein 2 is a protein that in humans is encoded by the MBD2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134046 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024513 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hendrich B, Bird A (November 1998). "Identification and Characterization of a Family of Mammalian Methyl-CpG Binding Proteins". Mol Cell Biol. 18 (11): 6538–47. doi:10.1128/mcb.18.11.6538. PMC 109239. PMID 9774669.
^ Hendrich B, Abbott C, McQueen H, Chambers D, Cross S, Bird A (September 1999). "Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes". Mamm Genome. 10 (9): 906–12. doi:10.1007/s003359901112. PMID 10441743. S2CID 819148.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134046 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024513 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9774669-5] Hendrich B, Bird A (November 1998). "Identification and Characterization of a Family of Mammalian Methyl-CpG Binding Proteins". Mol Cell Biol. 18 (11): 6538–47. doi:10.1128/mcb.18.11.6538. PMC 109239. PMID 9774669.

[pmid10441743-6] Hendrich B, Abbott C, McQueen H, Chambers D, Cross S, Bird A (September 1999). "Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes". Mamm Genome. 10 (9): 906–12. doi:10.1007/s003359901112. PMID 10441743. S2CID 819148.

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