Metronomic therapy

Metronomic therapy is a new type of chemotherapy in which anti-cancer drugs are administered in a lower dose than the maximum tolerated dose repetitively over a long period to treat cancers with fewer side effects. Metronomic therapy is shown to affect both tumor microenvironment and tumor cells to achieve its therapeutic effects.[1] Metronomic therapy is also cost-effective as a lower dose is used compared to conventional chemotherapy.[2] The use of metronomic therapy has been extensively investigated and can be advantageous in selected group of patients.[3] Yet, more clinical trials are necessary to generalize the method.[4]


  1. ^ Cite error: The named reference Simsek_2019 was invoked but never defined (see the help page).
  2. ^ Magrath I, Steliarova-Foucher E, Epelman S, Ribeiro RC, Harif M, Li CK, et al. (March 2013). "Paediatric cancer in low-income and middle-income countries". The Lancet. Oncology. 14 (3): e104-16. doi:10.1016/S1470-2045(13)70008-1. PMID 23434340.
  3. ^ Cite error: The named reference Lien_2013 was invoked but never defined (see the help page).
  4. ^ Cite error: The named reference CTG was invoked but never defined (see the help page).