Mezhyhirya (Ukrainian: Межигір'я) is a toponym of Ukrainian origin which means land between mounts or land between hills.
It can refer to:
- Mezhyhirya Monastery, a destroyed monastery in Kyiv Oblast
- Mezhyhirya ravine, located in Kyiv Oblast
- Mezhyhirya (residence), a former private residence of former Ukrainian President Viktor Yanukovych in Novi Petrivtsi, Vyshhorod Raion
- Mezhyhirya, a village in Rykiv community, Sambir Raion, Lviv Oblast
- Mezhyhirya, a village in Ustya-Zelene community, Chortkiv Raion, Ternopil Oblast