Microbial cell factory

Main article: Industrial microbiology
Schematic workflow for microbial factory optimization

Microbial cell factory is an approach to bioengineering which considers microbial cells as a production facility in which the optimization process largely depends on metabolic engineering.[1] MCFs is a derivation of cell factories, which are engineered microbes and plant cells.[2] In 1980s and 1990s, MCFs were originally conceived to improve productivity of cellular systems and metabolite yields through strain engineering.[3] A MCF develops native and nonnative metabolites through targeted strain design.[4] In addition, MCFs can shorten the synthesis cycle while reducing the difficulty of product separation.

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  1. ^ Villaverde, Antonio (2010-07-05). "Nanotechnology, bionanotechnology and microbial cell factories". Microbial Cell Factories. 9: 53. doi:10.1186/1475-2859-9-53. ISSN 1475-2859. PMC 2916890. PMID 20602780.
  2. ^ "Cell factory - benefits and potential of cell factories | VTT". www.vttresearch.com. Retrieved 2022-04-18.
  3. ^ Bailey, James E. (1991-06-21). "Toward a Science of Metabolic Engineering". Science. 252 (5013): 1668–1675. Bibcode:1991Sci...252.1668B. doi:10.1126/science.2047876. ISSN 0036-8075. PMID 2047876. S2CID 42386044.
  4. ^ Gohil, Nisarg; Bhattacharjee, Gargi; Singh, Vijai (2021), "An introduction to microbial cell factories for production of biomolecules", Microbial Cell Factories Engineering for Production of Biomolecules, Elsevier, pp. 1–19, doi:10.1016/b978-0-12-821477-0.00021-0, ISBN 978-0-12-821477-0, S2CID 234144332, retrieved 2022-04-18
  5. ^ Liu, Xiaonan; Ding, Wentao; Jiang, Huifeng (2017-07-19). "Engineering microbial cell factories for the production of plant natural products: from design principles to industrial-scale production". Microbial Cell Factories. 16 (1): 125. doi:10.1186/s12934-017-0732-7. ISSN 1475-2859. PMC 5518134. PMID 28724386.