The Microgravity Science Glovebox (MSG) is a glovebox aboard the International Space Station (ISS). It provides a safe contained environment for research with liquids, combustion and hazardous materials in the microgravity conditions of the ISS. Without the MSG, many types of hands-on investigations would be impossible or severely limited on board the Station. The Microgravity Science Glovebox (MSG) occupies a floor-to-ceiling rack inside the Destiny module of the ISS. It is more than twice as large as gloveboxes flown on the Space Shuttle and could contain larger investigations that are about twice the size of an airline carry-on bag.[1] A follow-on sister facility, managed by the same group at Marshall Space Flight Center, is intended to further support biological experiments with the Life Sciences Glovebox.[2]