Microtubule-associated protein 2

MAP2
Identifiers
Aliases	MAP2, MAP2A, MAP2B, MAP2C, microtubule associated protein 2, MAP-2
External IDs	OMIM: 157130; MGI: 97175; HomoloGene: 1779; GeneCards: MAP2; OMA:MAP2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	209,734,118 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	66,481,742 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; endothelial cell; ; superior vestibular nucleus; ; entorhinal cortex; ; pons; ; pars compacta; ; parietal lobe; ; postcentral gyrus; ; middle temporal gyrus; ; pars reticulata;
	Top expressed in
	anterior amygdaloid area; ; ventromedial nucleus; ; nucleus accumbens; ; lateral septal nucleus; ; superior frontal gyrus; ; paraventricular nucleus of hypothalamus; ; olfactory tubercle; ; dorsomedial hypothalamic nucleus; ; olfactory bulb; ; subiculum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	tubulin binding; protein binding; structural molecule activity; dystroglycan binding; calmodulin binding; microtubule binding; tau protein binding;
Cellular component	nucleolus; microtubule; microtubule associated complex; cytoskeleton; cytoplasm; cytosol; dendrite; cell projection; intracellular anatomical structure; postsynaptic density; nuclear periphery; neuron projection; soma; dendritic shaft; cell body; CA3 pyramidal cell dendrite; dendrite cytoplasm; axon initial segment; axon hillock; dendritic growth cone; main axon; dendritic branch; basal dendrite; primary dendrite; distal dendrite; apical distal dendrite; dendritic filopodium; proximal dendrite; proximal neuron projection;
Biological process	neuron projection development; microtubule cytoskeleton organization; microtubule bundle formation; dendrite morphogenesis; central nervous system neuron development; axonogenesis; dendrite development; establishment of cell polarity; regulation of axonogenesis; cellular response to organic substance; negative regulation of axon extension; regulation of microtubule polymerization; negative regulation of microtubule polymerization; positive regulation of anterograde dense core granule transport; regulation of organelle transport along microtubule; positive regulation of anterograde synaptic vesicle transport; negative regulation of microtubule binding;
	Sources:Amigo / QuickGO
Orthologs
	4133
	17756
	ENSG00000078018
	ENSMUSG00000015222
	P11137
	P20357
NM_001039538; NM_002374; NM_031845; NM_031846; NM_031847;
	NM_001363910; NM_001363911; NM_001363913
	NM_001039934; NM_008632; NM_001310634
NP_001034627; NP_002365; NP_114033; NP_114035; NP_001350839;
	NP_001350840; NP_001350842; NP_001362403; NP_001362422; NP_001362423; NP_001362424; NP_001362425; NP_001362426; NP_001362427; NP_001362428; NP_001362429; NP_001362430; NP_001362431; NP_001362432; NP_001362433; NP_001362434; NP_001362435; NP_001362436; NP_001362437; NP_001362438; NP_001362439; NP_001362455; NP_001362456; NP_001362457; NP_001362458; NP_001362459; NP_001362460; NP_001362461; NP_001362462; NP_001362463; NP_001362464; NP_001362465; NP_001362466; NP_001362467; NP_001362468; NP_001362469; NP_001362470; NP_001362471; NP_001362472; NP_001362473; NP_001362474; NP_001362475; NP_001362477; NP_001362480; NP_001362481; NP_001362482; NP_001362483; NP_001362484; NP_001362485; NP_001362486; NP_001362487; NP_001362488; NP_001362512
	NP_001035023; NP_001297563; NP_032658
	Wikidata
View/Edit Human	View/Edit Mouse

Microtubule-associated protein 2 is a protein in humans that is encoded by the MAP2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000078018 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015222 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Neve RL, Harris P, Kosik KS, Kurnit DM, Donlon TA (May 1987). "Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2". Brain Res. 387 (3): 271–80. doi:10.1016/0169-328x(86)90033-1. PMID 3103857.
^ Kalcheva N, Albala J, O'Guin K, Rubino H, Garner C, Shafit-Zagardo B (December 1995). "Genomic structure of human microtubule-associated protein 2 (MAP-2) and characterization of additional MAP-2 isoforms". Proc Natl Acad Sci U S A. 92 (24): 10894–8. Bibcode:1995PNAS...9210894K. doi:10.1073/pnas.92.24.10894. PMC 40537. PMID 7479905.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000078018 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015222 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3103857-5] Neve RL, Harris P, Kosik KS, Kurnit DM, Donlon TA (May 1987). "Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2". Brain Res. 387 (3): 271–80. doi:10.1016/0169-328x(86)90033-1. PMID 3103857.

[pmid7479905-6] Kalcheva N, Albala J, O'Guin K, Rubino H, Garner C, Shafit-Zagardo B (December 1995). "Genomic structure of human microtubule-associated protein 2 (MAP-2) and characterization of additional MAP-2 isoforms". Proc Natl Acad Sci U S A. 92 (24): 10894–8. Bibcode:1995PNAS...9210894K. doi:10.1073/pnas.92.24.10894. PMC 40537. PMID 7479905.

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