In developmental biology, midblastula or midblastula transition (MBT) occurs during the blastula stage of embryonic development in non-mammals. During this stage, the embryo is referred to as a blastula. The series of changes to the blastula that characterize the midblastula transition include activation of zygotic gene transcription, slowing of the cell cycle, increased asynchrony in cell division, and an increase in cell motility.