Mihajlo D. Mesarovic (Serbian Latin: Mihajlo D. Mesarović, Serbian Cyrillic: Михајло Д. Месаровић; born 2 July 1928) is a Serbian scientist, who is a professor of Systems Engineering and Mathematics at Case Western Reserve University. Mesarovic has been a pioneer in the field of systems theory, he was UNESCO Scientific Advisor on Global change and also a member of the Club of Rome.