Minetta Creek was one of the largest natural watercourses in Manhattan, New York City, United States. Minetta Creek was fed from two tributaries, one originating at Fifth Avenue and 21st Street, and the other originating at Sixth Avenue and 16th Street. They joined near Fifth Avenue and 11th Street then took a southwesterly course. Minetta Creek's name is thought to have originated from either the Native American term "Manette", meaning "Devil's Water", or the Dutch word "Minnetje", meaning "the little one".
Minetta Creek was originally known by the Dutch as Bestevaer's Killetje. During the 18th century, large amounts of wildlife could be seen around the creek. In the early 1820s, the New York City common council commissioned a project to divert Minetta Creek into a covered sewer. The creek was filled in by the mid-19th century, although it persisted as an underground stream through the 20th century.
Ever since the creek was covered in the 19th century, there have been debates over whether the creek still exists. Minetta Creek caused flooding in basements and construction sites from the mid-19th century through the mid-20th century. Pools of water were also found at several construction sites along the creek's course.