| MCM2-7 family | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 Overall Structure of the Mcm2-7 double hexamer[1] | |||||||||||
| Identifiers | |||||||||||
| Symbol | MCM | ||||||||||
| Pfam | PF00493 | ||||||||||
| Pfam clan | CL0023 | ||||||||||
| InterPro | IPR031327 | ||||||||||
| SMART | SM00350 | ||||||||||
| PROSITE | PDOC00662 | ||||||||||
| |||||||||||
| Pfam maps to the core ATP binding domain. | |||||||||||
The minichromosome maintenance protein complex (MCM) is a DNA helicase essential for genomic DNA replication. Eukaryotic MCM consists of six gene products, Mcm2–7, which form a heterohexamer.[1][2] As a critical protein for cell division, MCM is also the target of various checkpoint pathways, such as the S-phase entry and S-phase arrest checkpoints. Both the loading and activation of MCM helicase are strictly regulated and are coupled to cell growth cycles. Deregulation of MCM function has been linked to genomic instability and a variety of carcinomas.[3][4]
- ^ a b Li N, Zhai Y, Zhang Y, Li W, Yang M, Lei J, Tye BK, Gao N (August 2015). "Structure of the eukaryotic MCM complex at 3.8 Å". Nature. 524 (7564): 186–91. Bibcode:2015Natur.524..186L. doi:10.1038/nature14685. PMID 26222030. S2CID 4468690.
- ^ Zhai Y, Cheng E, Wu H, Li N, Yung PY, Gao N, Tye BK (March 2017). "Open-ringed structure of the Cdt1-Mcm2-7 complex as a precursor of the MCM double hexamer". Nature Structural & Molecular Biology. 24 (3): 300–308. doi:10.1038/nsmb.3374. PMID 28191894. S2CID 3929807.
- ^ Bochman ML, Schwacha A (December 2009). "The Mcm complex: unwinding the mechanism of a replicative helicase". Microbiology and Molecular Biology Reviews. 73 (4): 652–83. doi:10.1128/mmbr.00019-09. PMC 2786579. PMID 19946136.
- ^ Shima N, Alcaraz A, Liachko I, Buske TR, Andrews CA, Munroe RJ, Hartford SA, Tye BK, Schimenti JC (January 2007). "A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice". Nature Genetics. 39 (1): 93–8. doi:10.1038/ng1936. PMID 17143284. S2CID 11433033.