| Classification | Class D (1921) |
|---|---|
| Sport | Minor League Baseball |
| First season | 1921 |
| Ceased | 1921 |
| Replaced by | Cotton States League |
| President | John G Dailey (1921) |
| No. of teams | 4 |
| Country | United States of America |
| Most titles | 1 Clarksdale Cubs (1921) |
The Mississippi State League was a professional, Class D level minor baseball league that played in the 1921 season. The league consisted of teams based exclusively in Mississippi.