Missouri Route 53

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Route 53
Route information
Maintained by MoDOT
Length	34.602 mi[1] (55.687 km)
Existed	1922–present
Major junctions
South end	Route 25 in Holcomb
Major intersections	US 62 in Campbell
North end	US 67 Bus. in Poplar Bluff
Location
Country	United States
State	Missouri
Highway system
Missouri State Highway System Interstate US State Supplemental
← Route 52 → US 54

Route 53 is a highway in southeastern Missouri. Its southern terminus is at Route 25 in Holcomb. Its northern terminus is at Business U.S. Route 67 Business in Poplar Bluff.

Route 53 is one of the original state highways and has remained essentially unchanged since 1922.