| Mitochondrial replacement therapy | |
|---|---|
| Other names | Mitochondrial donation |
| MeSH | D000069321 |
Mitochondrial replacement therapy (MRT), sometimes called mitochondrial donation, is the replacement of mitochondria in one or more cells to prevent or ameliorate disease. MRT originated as a special form of in vitro fertilisation in which some or all of the future baby's mitochondrial DNA (mtDNA) comes from a third party. This technique is used in cases when mothers carry genes for mitochondrial diseases. The therapy is approved for use in the United Kingdom.[1][2] A second application is to use autologous mitochondria to replace mitochondria in damaged tissue to restore the tissue to a functional state. This has been used in clinical research in the United States to treat cardiac-compromised newborns.[3]
- ^ Claiborne, Anne; English, Rebecca; Kahn, Jeffrey, eds. (2016). Mitochondrial Replacement Techniques: Ethical, Social, and Policy Considerations. National Academies Press. ISBN 978-0-309-38870-2. Index page Archived 2018-11-26 at the Wayback Machine with links to summaries including one page summary flyer.
- ^ Cree, L; Loi, P (January 2015). "Mitochondrial replacement: from basic research to assisted reproductive technology portfolio tool-technicalities and possible risks". Molecular Human Reproduction. 21 (1): 3–10. doi:10.1093/molehr/gau082. PMID 25425606.
- ^ Kolata, Gina (10 July 2018). "Dying Organs Restored to Life in Novel Experiments". The New York Times. Retrieved 2018-07-12.
