Mixed lineage kinase domain like pseudokinase

MLKL
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MSV, 4M67, 4MWI
Identifiers
Aliases	MLKL, hmixed lineage kinase domain-like, mixed lineage kinase domain like pseudokinase
External IDs	OMIM: 615153; MGI: 1921818; HomoloGene: 77416; GeneCards: MLKL; OMA:MLKL - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	74,700,960 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	112,064,809 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; blood; ; spleen; ; upper lobe of left lung; ; appendix; ; myocardium of left ventricle; ; right lung; ; pancreatic epithelial cell; ; mucosa of ileum;
	Top expressed in
	bone marrow; ; epithelium of stomach; ; stroma of bone marrow; ; endothelial cell of lymphatic vessel; ; duodenum; ; transitional epithelium of urinary bladder; ; Paneth cell; ; subcutaneous adipose tissue; ; colon; ; jejunum;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; protein binding; ATP binding; protein kinase binding; protein kinase activity; identical protein binding; signal transducer activity; protein-containing complex binding; protein serine/threonine kinase activity; JUN kinase kinase kinase activity;
Cellular component	cytoplasm; cytosol; plasma membrane; membrane;
Biological process	necroptosis; protein homotrimerization; programmed cell death; protein phosphorylation; intracellular signal transduction; cell surface receptor signaling pathway; MAPK cascade;
	Sources:Amigo / QuickGO
Orthologs
	197259
	74568
	ENSG00000168404
	ENSMUSG00000012519
	Q8NB16
	Q9D2Y4
	NM_001142497; NM_152649
	NM_029005; NM_001310613
	NP_001135969; NP_689862
	NP_001297542; NP_083281
	Wikidata
View/Edit Human	View/Edit Mouse

Mixed lineage kinase domain like pseudokinase (MLKL) is a protein that in humans is encoded by the MLKL gene. ^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168404 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000012519 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Mixed lineage kinase domain like pseudokinase". Retrieved 2017-12-31.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168404 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000012519 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Mixed lineage kinase domain like pseudokinase". Retrieved 2017-12-31.

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