Model for End-Stage Liver Disease

Model for End-Stage Liver Disease
SynonymsMELD
PurposeAssess the severity of chronic liver disease
Based onSerum creatinine, INR, and bilirubin

The Model for End-Stage Liver Disease, or MELD, is a scoring system for assessing the severity of chronic liver disease. It was initially developed to predict mortality within three months of surgery in patients who had undergone a transjugular intrahepatic portosystemic shunt (TIPS) procedure,[1] and was subsequently found to be useful in determining prognosis and prioritizing for receipt of a liver transplant.[2][3] This score is now used by the United Network for Organ Sharing (UNOS) and Eurotransplant for prioritizing allocation of liver transplants instead of the older Child-Pugh score.[3][4]

  1. ^ Malinchoc, Michael; Kamath, Patrick S; Gordon, Fredric D; Peine, Craig J; Rank, Jeffrey; Ter Borg, Pieter C.J (2000). "A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shunts". Hepatology. 31 (4): 864–71. doi:10.1053/he.2000.5852. PMID 10733541.
  2. ^ Kamath, P; Wiesner, R. H; Malinchoc, M; Kremers, W; Therneau, T. M; Kosberg, C. L; d'Amico, G; Dickson, E. R; Kim, W. R (2001). "A model to predict survival in patients with end-stage liver disease". Hepatology. 33 (2): 464–70. doi:10.1053/jhep.2001.22172. PMID 11172350. S2CID 72518575.
  3. ^ a b Kamath, Patrick S; Kim, W. Ray (2007). "The model for end-stage liver disease (MELD)". Hepatology. 45 (3): 797–805. doi:10.1002/hep.21563. PMID 17326206.
  4. ^ Jung, G.E; Encke, J; Schmidt, J; Rahmel, A (2008). "Model for end-stage liver disease". Der Chirurg. 79 (2): 157–63. doi:10.1007/s00104-008-1463-4. PMID 18214398. S2CID 25562795.