Molindone

Molindone
Clinical data
Pronunciation/moʊˈlɪndoʊn/ moh-LIN-dohn
Trade namesMoban
Other namesEN-1733 A; EN1773-A; EN1773A
AHFS/Drugs.comConsumer Drug Information
MedlinePlusa682238
Pregnancy
category
  • C
Routes of
administration		By mouth (tablets)[1]
Drug classTypical antipsychotic
ATC code
Legal status
Legal status
Pharmacokinetic data
MetabolismHepatic
Elimination half-life2 hours[2]
Duration of action24–36 hours[1]
ExcretionMinor, renal and fecal[1]
Identifiers
  • 3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-
    1,5,6,7-tetrahydro-4H-indol-4-one
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.254.109 Edit this at Wikidata
Chemical and physical data
FormulaC16H24N2O2
Molar mass276.380 g·mol−1
3D model (JSmol)
  • O=C2c1c(c([nH]c1CCC2CN3CCOCC3)C)CC
  • InChI=1S/C16H24N2O2/c1-3-13-11(2)17-14-5-4-12(16(19)15(13)14)10-18-6-8-20-9-7-18/h12,17H,3-10H2,1-2H3 checkY
  • Key:KLPWJLBORRMFGK-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Molindone, sold under the brand name Moban, is an antipsychotic medication which is used in the United States in the treatment of schizophrenia.[2][1][3][4] It is taken by mouth.[1][2]

Side effects of molindone include extrapyramidal symptoms and tardive dyskinesia, among others.[2][1] Molindone is thought to work by blocking the effects of dopamine in the brain, leading to diminished symptoms of psychosis.[2] The drug is sometimes described as a typical antipsychotic,[5] and sometimes described as an atypical antipsychotic.[6] Chemically, molindone is an indole and is structurally distinct from many other antipsychotics.[2]

Molindone was first described by 1966[7] and was introduced for medical use in 1974.[8] It remains marketed only in the United States.[9] The drug has been repurposed and is being developed for potential treatment of aggression in children and adolescents with attention deficit hyperactivity disorder (ADHD).[10][11][12]

  1. ^ a b c d e f https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/017111s066lbl.pdf
  2. ^ a b c d e f Cite error: The named reference OwenCole1989 was invoked but never defined (see the help page).
  3. ^ "molindone". F.A. Davis Company.
  4. ^ "Molindone".
  5. ^ Aparasu RR, Jano E, Johnson ML, Chen H (October 2008). "Hospitalization risk associated with typical and atypical antipsychotic use in community-dwelling elderly patients". Am J Geriatr Pharmacother. 6 (4): 198–204. doi:10.1016/j.amjopharm.2008.10.003. PMID 19028375.
  6. ^ Bagnall A, Fenton M, Kleijnen J, Lewis R (2007). Bagnall AM (ed.). "Molindone for schizophrenia and severe mental illness". Cochrane Database Syst Rev (1): CD002083. doi:10.1002/14651858.CD002083.pub2. PMID 17253473.
  7. ^ Cite error: The named reference Elks2014 was invoked but never defined (see the help page).
  8. ^ Cite error: The named reference FederalRegister2013 was invoked but never defined (see the help page).
  9. ^ Cite error: The named reference Drugs.com-International was invoked but never defined (see the help page).
  10. ^ Cite error: The named reference RobbSchwabeCeresoli-Borroni2019 was invoked but never defined (see the help page).
  11. ^ Cite error: The named reference BaliaCarucciCoghill2018 was invoked but never defined (see the help page).
  12. ^ Cite error: The named reference AdisInsight was invoked but never defined (see the help page).