A monoamine neurotoxin, or monoaminergic neurotoxin, is a drug that selectively damages or destroys monoaminergic neurons.[1] Monoaminergic neurons are neurons that signal via stimulation by monoamine neurotransmitters including serotonin, dopamine, and norepinephrine.[1]
Examples of monoamine neurotoxins include the serotonergic neurotoxins para-chloroamphetamine (PCA), methylenedioxymethamphetamine (MDMA), and 5,7-dihydroxytryptamine (5,7-DHT);[2] the dopaminergic neurotoxins oxidopamine (6-hydroxydopamine), MPTP, and methamphetamine; and the noradrenergic neurotoxins oxidopamine and DSP-4.[1]
Dopaminergic neurotoxins can induce a Parkinson's disease-like condition in animals and humans.[1][3] Serotonergic neurotoxins have been associated with cognitive and memory deficits and psychiatric changes.[4][5][6][7]
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was invoked but never defined (see the help page).AguilarGarcía-PardoParrott2020
was invoked but never defined (see the help page).