Monoamine oxidase A

MAOA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Z5Y, 2BXR, 2BXS, 2Z5X
Identifiers
Aliases	MAOA, MAO-A, monoamine oxidase A, BRNRS
External IDs	OMIM: 309850; MGI: 96915; HomoloGene: 203; GeneCards: MAOA; OMA:MAOA - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.3 Start 43,654,907 bp[1] End 43,746,817 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X A1.2|X 11.78 cM Start 16,485,937 bp[2] End 16,554,057 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum mucosa of colon mucosa of sigmoid colon right lung jejunal mucosa duodenum rectum parotid gland gastric mucosa mucosa of transverse colon Top expressed in left colon superior cervical ganglion jejunum duodenum intestinal villus Ileal epithelium stroma of bone marrow endothelial cell of lymphatic vessel crypt of lieberkuhn of small intestine Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function primary amine oxidase activity oxidoreductase activity Cellular component integral component of membrane mitochondrial outer membrane membrane mitochondrion Biological process catecholamine metabolic process dopamine catabolic process neurotransmitter catabolic process cellular biogenic amine metabolic process neurotransmitter metabolic process cytokine-mediated signaling pathway positive regulation of signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4128 17161 Ensembl ENSG00000189221 ENSMUSG00000025037 UniProt P21397 Q64133 RefSeq (mRNA) NM_001270458 NM_000240 NM_173740 RefSeq (protein) NP_000231 NP_001257387 NP_776101 Location (UCSC) Chr X: 43.65 – 43.75 Mb Chr X: 16.49 – 16.55 Mb PubMed search [3] [4]
Wikidata
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Monoamine oxidase A, also known as MAO-A, is an enzyme (E.C. 1.4.3.4) that in humans is encoded by the MAOA gene.^[5][6] This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. A mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed.^[7]