| Monoblast | |
|---|---|
 Monoblast | |
| Details | |
| System | Immune system |
| Location | Bone marrow |
| Function | A precursor monocyte |
| Identifiers | |
| TH | H2.00.04.3.08002 |
| FMA | 83553 |
| Anatomical terms of microanatomy | |
Monoblasts are the committed progenitor cells that differentiated from a committed macrophage or dendritic cell precursor (MDP[1]) in the process of hematopoiesis. They are the first developmental stage in the monocyte series leading to a macrophage.[2] Their myeloid cell fate is induced by the concentration of cytokines they are surrounded by during development. These cytokines induce the activation of transcription factors which push completion of the monoblast's myeloid cell fate. Monoblasts are normally found in bone marrow and do not appear in the normal peripheral blood.[3] They mature into monocytes which, in turn, develop into macrophages.[4] They then are seen as macrophages in the normal peripheral blood and many different tissues of the body. Macrophages can produce a variety of effector molecules that initiate local, systemic inflammatory responses. These monoblast differentiated cells are equipped to fight off foreign invaders using pattern recognition receptors to detect antigen as part of the innate immune response.[1]
- ^ a b Yang J, Zhang L, Yu C, Yang XF, Wang H (January 2014). "Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases". Biomarker Research. 2 (1): 1. doi:10.1186/2050-7771-2-1. PMC 3892095. PMID 24398220.
- ^ "Monoblast". Biology Articles, Tutorials & Dictionary Online. 2019-10-07. Retrieved 2021-02-27.
- ^ Abbas AK, Lichtman AH, Pillai S (2012). Cellular and molecular immunology (7th ed.). Philadelphia: Elsevier/Saunders. ISBN 9781437715286. OCLC 698580696.
- ^ Mescher AL, Junqueira LC (2013-02-22). Junqueira's basic histology: text and atlas (Thirteenth ed.). New York: McGraw-Hill Medical. ISBN 9780071807203. OCLC 854567882.