Monocarboxylate transporter 8

SLC16A2
Identifiers
Aliases	SLC16A2, DXS128, DXS128E, MCT 7, MCT 8, MCT7, MCT8, MRX22, XPCT, AHDS, solute carrier family 16 member 2
External IDs	OMIM: 300095; MGI: 1203732; HomoloGene: 39495; GeneCards: SLC16A2; OMA:SLC16A2 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	74,533,917 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	102,865,589 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; right adrenal cortex; ; right lobe of liver; ; left adrenal gland; ; left adrenal cortex; ; ganglionic eminence; ; ventricular zone; ; anterior pituitary; ; stromal cell of endometrium; ; gallbladder;
	Top expressed in
	choroid plexus of fourth ventricle; ; Epithelium of choroid plexus; ; left lobe of liver; ; right kidney; ; tail of embryo; ; ligament; ; human kidney; ; internal carotid artery; ; proximal tubule; ; genital tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	symporter activity; monocarboxylic acid transmembrane transporter activity; transporter activity; thyroid hormone transmembrane transporter activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; plasma membrane;
Biological process	monocarboxylic acid transport; thyroid hormone transport; transmembrane transport; sodium-independent organic anion transport;
	Sources:Amigo / QuickGO
Orthologs
	6567
	20502
	ENSG00000147100
	ENSMUSG00000033965
	P36021
	O70324
	NM_006517
	NM_009197
	NP_006508; NP_006508.2
	NP_033223
	Wikidata
View/Edit Human	View/Edit Mouse

Monocarboxylate transporter 8 (MCT8) is an active transporter protein that in humans is encoded by the SLC16A2 gene.^[5]^[6]^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147100 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033965 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lafrenière RG, Carrel L, Willard HF (Jul 1994). "A novel transmembrane transporter encoded by the XPCT gene in Xq13.2". Human Molecular Genetics. 3 (7): 1133–9. doi:10.1093/hmg/3.7.1133. PMID 7981683.
^ Friesema EC, Ganguly S, Abdalla A, Manning Fox JE, Halestrap AP, Visser TJ (Oct 2003). "Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter". The Journal of Biological Chemistry. 278 (41): 40128–35. doi:10.1074/jbc.M300909200. PMID 12871948.
^ Schwartz CE, May MM, Carpenter NJ, Rogers RC, Martin J, Bialer MG, Ward J, Sanabria J, Marsa S, Lewis JA, Echeverri R, Lubs HA, Voeller K, Simensen RJ, Stevenson RE (Jul 2005). "Allan-Herndon-Dudley syndrome and the monocarboxylate transporter 8 (MCT8) gene". American Journal of Human Genetics. 77 (1): 41–53. doi:10.1086/431313. PMC 1226193. PMID 15889350.
^ "Entrez Gene: SLC16A2 solute carrier family 16, member 2 (monocarboxylic acid transporter 8)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000147100 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033965 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7981683-5] Lafrenière RG, Carrel L, Willard HF (Jul 1994). "A novel transmembrane transporter encoded by the XPCT gene in Xq13.2". Human Molecular Genetics. 3 (7): 1133–9. doi:10.1093/hmg/3.7.1133. PMID 7981683.

[pmid12871948-6] Friesema EC, Ganguly S, Abdalla A, Manning Fox JE, Halestrap AP, Visser TJ (Oct 2003). "Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter". The Journal of Biological Chemistry. 278 (41): 40128–35. doi:10.1074/jbc.M300909200. PMID 12871948.

[pmid15889350-7] Schwartz CE, May MM, Carpenter NJ, Rogers RC, Martin J, Bialer MG, Ward J, Sanabria J, Marsa S, Lewis JA, Echeverri R, Lubs HA, Voeller K, Simensen RJ, Stevenson RE (Jul 2005). "Allan-Herndon-Dudley syndrome and the monocarboxylate transporter 8 (MCT8) gene". American Journal of Human Genetics. 77 (1): 41–53. doi:10.1086/431313. PMC 1226193. PMID 15889350.

[entrez-8] "Entrez Gene: SLC16A2 solute carrier family 16, member 2 (monocarboxylic acid transporter 8)".

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