Moselle is a river in France, Luxembourg and Germany.
Moselle may also refer to:
- Moselle (department), French département surrounding the river
- Moselle (riverboat), American 19th-century riverboat
- Moselle wine from the region around the river
- River Moselle (London), England
- Moselle, Mississippi, unincorporated community in the United States
- Moselle, Missouri, unincorporated community in the United States
- Mosel, Wisconsin, township in the United States, sometimes spelled Moselle and named after the river
- Open de Moselle, ATP tennis tournament
- Moselle, the nicknamed household hunting property property on which disgraced South Carolina lawyer Alex Murdaugh murdered his wife, Maggie Murdaugh, and youngest son, Paul Murdaugh.