Mothers against decapentaplegic homolog 3

SMAD3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LB2, 1MHD, 1MJS, 1MK2, 1OZJ, 1U7F, 2LAJ, 5OD6, 5ODG
Identifiers
Aliases	SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3, SMAD family member 3
External IDs	OMIM: 603109; MGI: 1201674; HomoloGene: 55937; GeneCards: SMAD3; OMA:SMAD3 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q22.33 Start 67,063,763 bp[1] End 67,195,173 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 C Start 63,554,049 bp[2] End 63,665,276 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii cartilage tissue muscle of thigh mucosa of esophagus epithelium of colon gastrocnemius muscle synovial joint Skeletal muscle tissue of biceps brachii mucosa of urinary bladder olfactory zone of nasal mucosa Top expressed in genital tubercle temporal muscle triceps brachii muscle molar ankle sternocleidomastoid muscle tail of embryo internal carotid artery external carotid artery fossa More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatase binding DNA-binding transcription factor activity R-SMAD binding co-SMAD binding RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor binding metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding enzyme binding transforming growth factor beta receptor binding protein homodimerization activity collagen binding zinc ion binding chromatin binding cis-regulatory region sequence-specific DNA binding protein binding double-stranded DNA binding protein kinase binding sequence-specific DNA binding DNA binding bHLH transcription factor binding ubiquitin binding identical protein binding protein heterodimerization activity chromatin DNA binding ubiquitin protein ligase binding beta-catenin binding RNA polymerase II general transcription initiation factor activity DEAD/H-box RNA helicase binding mineralocorticoid receptor binding glucocorticoid receptor binding primary miRNA binding DNA-binding transcription factor activity, RNA polymerase II-specific SMAD binding DNA-binding transcription activator activity, RNA polymerase II-specific transcription coregulator activity Cellular component cytoplasm nucleus heteromeric SMAD protein complex SMAD protein complex transcription regulator complex receptor complex plasma membrane intracellular anatomical structure nucleoplasm nuclear inner membrane cytosol protein-containing complex Biological process somitogenesis skeletal system development ureteric bud development endoderm development regulation of transforming growth factor beta2 production embryonic pattern specification regulation of transcription by RNA polymerase II negative regulation of osteoblast differentiation heart looping positive regulation of chondrocyte differentiation positive regulation of alkaline phosphatase activity positive regulation of interleukin-1 beta production pericardium development regulation of binding negative regulation of wound healing activation of cysteine-type endopeptidase activity involved in apoptotic process transforming growth factor beta receptor signaling pathway negative regulation of inflammatory response positive regulation of positive chemotaxis negative regulation of cell population proliferation negative regulation of fat cell differentiation cell-cell junction organization regulation of transcription, DNA-templated extrinsic apoptotic signaling pathway activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway signal transduction involved in regulation of gene expression in utero embryonic development negative regulation of transforming growth factor beta receptor signaling pathway nodal signaling pathway positive regulation of transcription, DNA-templated negative regulation of cell growth regulation of immune response positive regulation of transforming growth factor beta3 production T cell activation activin receptor signaling pathway regulation of striated muscle tissue development embryonic foregut morphogenesis positive regulation of bone mineralization wound healing negative regulation of apoptotic process positive regulation of extracellular matrix assembly negative regulation of transcription by RNA polymerase II positive regulation of epithelial to mesenchymal transition mitigation of host defenses by virus thyroid gland development developmental growth lens fiber cell differentiation gastrulation immune response osteoblast differentiation primary miRNA processing negative regulation of osteoblast proliferation osteoblast development embryonic cranial skeleton morphogenesis transdifferentiation paraxial mesoderm morphogenesis response to hypoxia positive regulation of cell migration mesoderm formation regulation of transforming growth factor beta receptor signaling pathway positive regulation of gene expression immune system development positive regulation of focal adhesion assembly liver development regulation of epithelial cell proliferation positive regulation of stress fiber assembly positive regulation of transcription by RNA polymerase II negative regulation of mitotic cell cycle negative regulation of cytosolic calcium ion concentration canonical Wnt signaling pathway protein stabilization transcription, DNA-templated negative regulation of protein catabolic process protein deubiquitination positive regulation of nitric oxide biosynthetic process negative regulation of lung blood pressure positive regulation of pri-miRNA transcription by RNA polymerase II negative regulation of cardiac muscle hypertrophy in response to stress cellular response to transforming growth factor beta stimulus cellular response to cytokine stimulus positive regulation of protein import into nucleus positive regulation of DNA-binding transcription factor activity SMAD protein signal transduction positive regulation of canonical Wnt signaling pathway SMAD protein complex assembly adrenal gland development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4088 17127 Ensembl ENSG00000166949 ENSMUSG00000032402 UniProt P84022 Q8BUN5 RefSeq (mRNA) NM_001145102 NM_001145103 NM_001145104 NM_005902 NM_016769 RefSeq (protein) NP_001138574 NP_001138575 NP_001138576 NP_005893 NP_058049 Location (UCSC) Chr 15: 67.06 – 67.2 Mb Chr 9: 63.55 – 63.67 Mb PubMed search [3] [4]
Wikidata
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Mothers against decapentaplegic homolog 3 also known as SMAD family member 3 or SMAD3 is a protein that in humans is encoded by the SMAD3 gene.^[5][6]

SMAD3 is a member of the SMAD family of proteins. It acts as a mediator of the signals initiated by the transforming growth factor beta (TGF-β) superfamily of cytokines, which regulate cell proliferation, differentiation and death.^[7][8] Based on its essential role in TGF beta signaling pathway, SMAD3 has been related with tumor growth in cancer development.