Mothers against decapentaplegic homolog 7

SMAD7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DJY, 2LTV, 2LTW, 2LTX, 2LTY, 2LTZ, 2KXQ
Identifiers
Aliases	SMAD7, CRCS3, MADH7, MADH8, SMAD family member 7
External IDs	OMIM: 602932; MGI: 1100518; HomoloGene: 4314; GeneCards: SMAD7; OMA:SMAD7 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q21.1 Start 48,919,853 bp[1] End 48,950,965 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 E3 Start 75,500,600 bp[2] End 75,529,006 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in popliteal artery tibial arteries saphenous vein Descending thoracic aorta right auricle ascending aorta cardiac muscle tissue of right atrium right lung left coronary artery right coronary artery Top expressed in molar gastrula left lung lobe pyloric antrum Gonadal ridge decidua cumulus cell lumbar subsegment of spinal cord substantia nigra blood More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding beta-catenin binding type I transforming growth factor beta receptor binding collagen binding I-SMAD binding activin binding DNA-binding transcription factor activity metal ion binding protein binding ubiquitin protein ligase binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm centrosome transcription regulator complex plasma membrane intracellular anatomical structure nucleoplasm catenin complex nucleus fibrillar center cytosol protein-containing complex Biological process cellular response to transforming growth factor beta stimulus regulation of ventricular cardiac muscle cell membrane depolarization pathway-restricted SMAD protein phosphorylation ureteric bud development regulation of transcription, DNA-templated adherens junction assembly positive regulation of cell-cell adhesion ventricular septum morphogenesis regulation of epithelial to mesenchymal transition negative regulation of peptidyl-threonine phosphorylation negative regulation of transcription by competitive promoter binding response to laminar fluid shear stress protein stabilization regulation of activin receptor signaling pathway negative regulation of transcription by RNA polymerase II negative regulation of transforming growth factor beta receptor signaling pathway BMP signaling pathway negative regulation of DNA-binding transcription factor activity negative regulation of pathway-restricted SMAD protein phosphorylation negative regulation of BMP signaling pathway ventricular cardiac muscle tissue morphogenesis negative regulation of protein ubiquitination negative regulation of cell migration negative regulation of ubiquitin-protein transferase activity artery morphogenesis negative regulation of peptidyl-serine phosphorylation regulation of cardiac muscle contraction positive regulation of protein ubiquitination positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of epithelial to mesenchymal transition positive regulation of transcription by RNA polymerase II regulation of transforming growth factor beta receptor signaling pathway transcription, DNA-templated transforming growth factor beta receptor signaling pathway protein deubiquitination negative regulation of T cell cytokine production negative regulation of T-helper 17 type immune response negative regulation of T-helper 17 cell differentiation cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4092 17131 Ensembl ENSG00000101665 ENSMUSG00000025880 UniProt O15105 O35253 RefSeq (mRNA) NM_005904 NM_001190821 NM_001190822 NM_001190823 NM_001042660 NM_008543 RefSeq (protein) NP_001177750 NP_001177751 NP_001177752 NP_005895 NP_001036125 Location (UCSC) Chr 18: 48.92 – 48.95 Mb Chr 18: 75.5 – 75.53 Mb PubMed search [3] [4]
Wikidata
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Mothers against decapentaplegic homolog 7 or SMAD7 is a protein that in humans is encoded by the SMAD7 gene.^[5]

SMAD7 is a protein that, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic". It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of ligands. Like many other TGFβ family members, SMAD7 is involved in cell signalling. It is a TGFβ type 1 receptor antagonist. It blocks TGFβ1 and activin associating with the receptor, blocking access to SMAD2. It is an inhibitory SMAD (I-SMAD) and is enhanced by SMURF2.

Smad7 enhances muscle differentiation.