Mouzalon or Muzalon (Greek: Μουζάλων, pl. Μουζάλωνες) was the name of a Byzantine family attested in the 11th through 15th centuries, which produced a number of officials and high dignitaries. The family reached its peak in the 1250s, when it enjoyed the patronage of Emperor Theodore II Laskaris (r. 1254–1258), but was largely purged after his death by the great aristocratic families. The female form of the name is Mouzalonissa (Μουζαλώνισσα).