Msh homeobox 2

MSX2
Identifiers
Aliases	MSX2, CRS2, FPP, HOX8, MSH, PFM, PFM1, Msh homeobox 2
External IDs	OMIM: 123101; MGI: 97169; HomoloGene: 1837; GeneCards: MSX2; OMA:MSX2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	174,730,896 bp
RNA expression pattern
	Top expressed in
	placenta; ; secondary oocyte; ; testicle; ; lactiferous duct; ; urinary bladder; ; tibial arteries; ; gonad; ; mucosa of urinary bladder; ; skin of abdomen; ; muscle of thigh;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; transcription coregulator activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; protein binding; transcription factor binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; cytosol; nuclear speck;
Biological process	negative regulation of cell population proliferation; positive regulation of timing of catagen; negative regulation of keratinocyte differentiation; negative regulation of transcription regulatory region DNA binding; embryonic limb morphogenesis; frontal suture morphogenesis; mammary gland epithelium development; BMP signaling pathway involved in heart development; enamel mineralization; ossification; anterior/posterior pattern specification; bone morphogenesis; regulation of transcription, DNA-templated; cellular response to growth factor stimulus; activation of meiosis; endochondral bone growth; wound healing, spreading of epidermal cells; BMP signaling pathway; embryonic digit morphogenesis; positive regulation of mesenchymal cell apoptotic process; multicellular organism development; embryonic hindlimb morphogenesis; negative regulation of CREB transcription factor activity; outflow tract morphogenesis; bone trabecula formation; wound healing; regulation of apoptotic process; chondrocyte development; osteoblast development; positive regulation of osteoblast differentiation; cranial suture morphogenesis; negative regulation of fat cell differentiation; branching involved in mammary gland duct morphogenesis; outflow tract septum morphogenesis; negative regulation of transcription, DNA-templated; osteoblast differentiation; epithelial to mesenchymal transition involved in endocardial cushion formation; positive regulation of BMP signaling pathway; signal transduction involved in regulation of gene expression; cellular response to estradiol stimulus; embryonic forelimb morphogenesis; embryonic nail plate morphogenesis; negative regulation of apoptotic process; cartilage development; stem cell differentiation; odontogenesis; transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; embryonic morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	4488
	17702
	ENSG00000120149
	n/a
	P35548
	Q03358
	NM_002449; NM_001363626
	NM_013601
	NP_002440; NP_001350555
	NP_038629
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein MSX-2 is a protein that in humans is encoded by the MSX2 gene.^[4]^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000120149 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Takahashi C, Akiyama N, Matsuzaki T, Takai S, Kitayama H, Noda M (May 1996). "Characterization of a human MSX-2 cDNA and its fragment isolated as a transformation suppressor gene against v-Ki-ras oncogene". Oncogene. 12 (10): 2137–46. PMID 8668339.
^ Kostrzewa M, Grady DL, Moyzis RK, Flöter L, Müller U (March 1996). "Integration of four genes, a pseudogene, thirty-one STSs, and a highly polymorphic STRP into the 7-10 Mb YAC contig of 5q34-q35". Human Genetics. 97 (3): 399–403. doi:10.1007/BF02185781. PMID 8786091. S2CID 12647370.
^ "Entrez Gene: MSX2 msh homeobox 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000120149 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8668339-4] Takahashi C, Akiyama N, Matsuzaki T, Takai S, Kitayama H, Noda M (May 1996). "Characterization of a human MSX-2 cDNA and its fragment isolated as a transformation suppressor gene against v-Ki-ras oncogene". Oncogene. 12 (10): 2137–46. PMID 8668339.

[pmid8786091-5] Kostrzewa M, Grady DL, Moyzis RK, Flöter L, Müller U (March 1996). "Integration of four genes, a pseudogene, thirty-one STSs, and a highly polymorphic STRP into the 7-10 Mb YAC contig of 5q34-q35". Human Genetics. 97 (3): 399–403. doi:10.1007/BF02185781. PMID 8786091. S2CID 12647370.

[entrez-6] "Entrez Gene: MSX2 msh homeobox 2".

[1]

[2]

[3]

[4]

[5]

[6]