MuSK protein

muscle, skeletal, receptor tyrosine kinase
Identifiers
SymbolMUSK
NCBI gene4593
HGNC7525
OMIM601296
RefSeqNM_005592
UniProtO15146
Other data
LocusChr. 9 q31.3-q32
Search for
StructuresSwiss-model
DomainsInterPro

MuSK (for Muscle-Specific Kinase)[1] is a receptor tyrosine kinase required for the formation and maintenance of the neuromuscular junction.[2] It is activated by a nerve-derived proteoglycan called agrin,[3] which is similarly also required for neuromuscular junction formation.[4]

  1. ^ Valenzuela DM, Stitt TN, DiStefano PS, Rojas E, Mattsson K, Compton DL, Nunez L, Park JS, Stark JL, Gies DR, Thomas S, LeBeau MM, Fernald AA, Copeland NG, Jenkins NA, Burden SJ, Glass DJ, Yancopoulos GD (Sep 1995). "Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury". Neuron. 15 (3): 573–584. doi:10.1016/0896-6273(95)90146-9. PMID 7546737. S2CID 17575761.
  2. ^ DeChiara TM, Bowen DC, Valenzuela DM, Simmons MV, Poueymirou WT, Thomas S, Kinetz E, Compton DL, Rojas E, Park JS, Smith C, DiStefano PS, Glass DJ, Burden SJ, Yancopoulos GD (May 1996). "The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo". Cell. 85 (4): 501–512. doi:10.1016/s0092-8674(00)81251-9. PMID 8653786. S2CID 17455481.
  3. ^ Glass DJ, Bowen DC, Stitt TN, Radziejewski C, Bruno J, Ryan TE, Gies DR, Shah S, Mattson K, Burden SJ, DiStefano PS, Valenzuela DM, DeChiara TM, Yancopoulos GD (May 1996). "Agrin acts via a MuSK receptor complex". Cell. 85 (4): 513–523. doi:10.1016/s0092-8674(00)81252-0. PMID 8653787. S2CID 14930468.
  4. ^ Gautam M, Noakes PG, Moscoso L, Rupp F, Scheller RH, Merlie JP, Sanes JR (May 1996). "Defective neuromuscular synaptogenesis in agrin-deficient mutant mice". Cell. 85 (4): 525–535. doi:10.1016/s0092-8674(00)81253-2. PMID 8653788. S2CID 12517490.