Protein-coding gene in the species Homo sapiens
Mucin-5B (MUC-5B) is a protein that in humans is encoded by the MUC5B gene
[ 5] [ 6] [ 7] [ 8] and by the Muc5b gene in the mouse. It is one of the five gel-forming mucins . MUC-5B can be found in whole saliva, normal lung mucus, and cervical mucus. In some diseases, such as COPD , chronic rhinosinusitis (CRS), and H. pylori -associated gastric disease, the gene has been found to be upregulated, and this may be related to the pathogenesis of these conditions.[ 9]
^ a b c GRCh38: Ensembl release 89: ENSG00000117983 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000066108 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Desseyn JL, Buisine MP, Porchet N, Aubert JP, Laine A (November 1998). "Genomic organization of the human mucin gene MUC5B. cDNA and genomic sequences upstream of the large central exon" . The Journal of Biological Chemistry . 273 (46): 30157–64. doi :10.1074/jbc.273.46.30157 . PMID 9804771 .
^ Desseyn JL, Guyonnet-Dupérat V, Porchet N, Aubert JP, Laine A (November 1997). "Human mucin gene MUC5B, the 10.7-kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene family" . The Journal of Biological Chemistry . 272 (4): 3168–78. doi :10.1074/jbc.272.6.3168 . PMID 9013550 .
^ Desseyn JL, Aubert JP, Van Seuningen I, Porchet N, Laine A (1997). "Genomic organization of the 3' region of the human mucin gene MUC5B" . The Journal of Biological Chemistry . 272 (27): 16873–83. doi :10.1074/jbc.272.27.16873 . PMID 9201995 .
^ "Entrez Gene: MUC5B mucin 5B, oligomeric mucus/gel-forming" .
^ "MUC5B mucin 5B, oligomeric mucus/gel-forming [Homo sapiens (human)] - Gene - NCBI" . www.ncbi.nlm.nih.gov . Retrieved 2021-06-10 .