Mucin 5B

MUC5B
Identifiers
AliasesMUC5B, MG1, MUC-5B, MUC5, MUC9, mucin 5B, oligomeric mucus/gel-forming
External IDsOMIM: 600770; MGI: 1921430; HomoloGene: 136756; GeneCards: MUC5B; OMA:MUC5B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002458

NM_028801

RefSeq (protein)

NP_002449

n/a

Location (UCSC)Chr 11: 1.22 – 1.26 MbChr 7: 141.39 – 141.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mucin-5B (MUC-5B) is a protein that in humans is encoded by the MUC5B gene [5][6][7][8] and by the Muc5b gene in the mouse. It is one of the five gel-forming mucins. MUC-5B can be found in whole saliva, normal lung mucus, and cervical mucus. In some diseases, such as COPD, chronic rhinosinusitis (CRS), and H. pylori-associated gastric disease, the gene has been found to be upregulated, and this may be related to the pathogenesis of these conditions.[9]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117983Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000066108Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Desseyn JL, Buisine MP, Porchet N, Aubert JP, Laine A (November 1998). "Genomic organization of the human mucin gene MUC5B. cDNA and genomic sequences upstream of the large central exon". The Journal of Biological Chemistry. 273 (46): 30157–64. doi:10.1074/jbc.273.46.30157. PMID 9804771.
  6. ^ Desseyn JL, Guyonnet-Dupérat V, Porchet N, Aubert JP, Laine A (November 1997). "Human mucin gene MUC5B, the 10.7-kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene family". The Journal of Biological Chemistry. 272 (4): 3168–78. doi:10.1074/jbc.272.6.3168. PMID 9013550.
  7. ^ Desseyn JL, Aubert JP, Van Seuningen I, Porchet N, Laine A (1997). "Genomic organization of the 3' region of the human mucin gene MUC5B". The Journal of Biological Chemistry. 272 (27): 16873–83. doi:10.1074/jbc.272.27.16873. PMID 9201995.
  8. ^ "Entrez Gene: MUC5B mucin 5B, oligomeric mucus/gel-forming".
  9. ^ "MUC5B mucin 5B, oligomeric mucus/gel-forming [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-06-10.