Clinical data | |
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Trade names | Bactroban, others |
Other names | muciprocin[1] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a688004 |
License data | |
Pregnancy category |
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Routes of administration | Topical |
ATC code | |
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Pharmacokinetic data | |
Protein binding | 97% |
Elimination half-life | 20 to 40 minutes |
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CAS Number | |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.106.215 |
Chemical and physical data | |
Formula | C26H44O9 |
Molar mass | 500.629 g·mol−1 |
3D model (JSmol) | |
Melting point | 77 to 78 °C (171 to 172 °F) |
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Mupirocin, sold under the brand name Bactroban among others, is a topical antibiotic useful against superficial skin infections such as impetigo or folliculitis.[5][6][7] It may also be used to get rid of methicillin-resistant S. aureus (MRSA) when present in the nose without symptoms.[6] Due to concerns of developing resistance, use for greater than ten days is not recommended.[7] It is used as a cream or ointment applied to the skin.[6]
Common side effects include itchiness and rash at the site of application, headache, and nausea.[6] Long term use may result in increased growth of fungi.[6] Use during pregnancy and breastfeeding appears to be safe.[6] Mupirocin is chemically a carboxylic acid.[8] It works by blocking a bacteria's ability to make protein, which usually results in bacterial death.[6]
Mupirocin was initially isolated in 1971 from Pseudomonas fluorescens.[9] It is on the World Health Organization's List of Essential Medicines.[10] In 2021, it was the 203rd most commonly prescribed medication in the United States, with more than 2 million prescriptions.[11][12] It is available as a generic medication.[13]